The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture

The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture

Summary: The nucleosome remodeling and deacetylase (NuRD) complex is essential for metazoan development but has been refractory to biochemical analysis. We present an integrated analysis of the native mammalian NuRD complex, combining quantitative mass spectrometry, cross-linking, protein biochemist...

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Bibliographic Details
Main Authors: Jason K.K. Low, Ana P.G. Silva, Mehdi Sharifi Tabar, Mario Torrado, Sarah R. Webb, Benjamin L. Parker, Maryam Sana, Callum Smits, Jason W. Schmidberger, Lou Brillault, Matthew J. Jackman, David C. Williams, Jr., Gerd A. Blobel, Sandra B. Hake, Nicholas E. Shepherd, Michael J. Landsberg, Joel P. Mackay
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
NuRD
PWWP2A
gene regulation
nucleosome remodeling
cross-linking MS
DIA-MS
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031439X

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http://www.sciencedirect.com/science/article/pii/S221112472031439X

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