NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation

NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation

Summary: In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the development of αβ thymocytes remains mostly unaffected. Th...

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Bibliographic Details
Main Authors: Sabrina Giampaolo, Cristina M. Chiarolla, Konrad Knöpper, Martin Vaeth, Matthias Klein, Azeem Muhammad, Tobias Bopp, Friederike Berberich-Siebelt, Amiya K. Patra, Edgar Serfling, Stefan Klein-Hessling
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
molecular biology
Immunology
developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223003115

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http://www.sciencedirect.com/science/article/pii/S2589004223003115

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