Synthesis and biological activity of sulfur compounds showing structural analogy with combretastatin A-4

Synthesis and biological activity of sulfur compounds showing structural analogy with combretastatin A-4

Show other versions (1)

We extended our previous exploration of sulfur bridges as bioisosteric replacements for atoms forming the bridge between the aromatic rings of combretastatin A-4. Employing coupling reactions between 5-iodo-1,2,3-trimethoxybenzene and substituted thiols, followed by oxidation to sulfones with m-CPBA...

Full description

Bibliographic Details
Main Authors: Edson dos A. dos Santos, Paulo C. Prado, Wanderley R. de Carvalho, Ricardo V. de Lima, Adilson Beatriz, Dênis P. de Lima, Ernest Hamel, Marzena A. Dyba, Sergio Albuquerque
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2013-01-01
Series:Química Nova
Subjects:
combretastatin A-4
antitubulin activity
leishmanicidal activity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000200014

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000200014

Similar Items