Synthesis and biological activity of sulfur compounds showing structural analogy with combretastatin A-4

Synthesis and biological activity of sulfur compounds showing structural analogy with combretastatin A-4

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We extended our previous exploration of sulfur bridges as bioisosteric replacements for atoms forming the bridge between the aromatic rings of combretastatin A-4. Employing coupling reactions between 5-iodo-1,2,3-trimethoxybenzene and substituted thiols, followed by oxidation to sulfones with m-CPBA...

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Bibliographic Details
Main Authors:	Edson dos A. dos Santos, Paulo C. Prado, Wanderley R. de Carvalho, Ricardo V. de Lima, Adilson Beatriz, Dênis P. de Lima, Ernest Hamel, Marzena A. Dyba, Sergio Albuquerque
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Química 2013-01-01
Series:	Química Nova
Subjects:	combretastatin A-4 antitubulin activity leishmanicidal activity
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000200014

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