A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide- and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides

A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide- and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides

Cell penetrating peptides (CPPs) are a promising technology for therapeutic delivery of macromolecular cargos. CPPs have generally used covalent linkages to cargo, ensuring a common fate as one molecule. Conversely, our CPP-adaptor, TAT-CaM, noncovalently binds calmodulin binding sequence (CBS)-cont...

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Bibliographic Details
Main Authors: Daniel P. Morris, Lucy C. Snipes, Stephanie A. Hill, Michael M. Woods, Maria M. Mbugua, Lydia R. Wade, Jonathan L. McMurry
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
cell-penetrating peptides
protein transduction domains (PTD)
endolytic peptides
endocytosis
calmodulin (CAM)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1070464/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1070464/full

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