A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia–reperfusion injury

A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia–reperfusion injury

Abstract The complement system is a potent mediator of ischemia–reperfusion injury (IRI), which detrimentally affects the function and survival of transplanted kidneys. Human complement receptor 1 (HuCR1) is an integral membrane protein that inhibits complement activation by blocking the convertases...

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Bibliographic Details
Main Authors: Anjan K. Bongoni, Ingela B. Vikstrom, Jennifer L. McRae, Evelyn J. Salvaris, Nella Fisicaro, Martin J. Pearse, Sandra Wymann, Tony Rowe, Adriana Baz Morelli, Matthew P. Hardy, Peter J. Cowan
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-01423-y

Internet

https://doi.org/10.1038/s41598-021-01423-y

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