Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development

Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development

The HECT-type ubiquitin ligase HECT, UBA and WWE Domain Containing 1, (HUWE1) regulates key cancer-related pathways, including the Myc oncogene. It affects cell proliferation, stress and immune signaling, mitochondria homeostasis, and cell death. HUWE1 is evolutionarily conserved from Caenorhabditis...

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Bibliographic Details
Main Authors: Yifat Yanku, Eliya Bitman-Lotan, Yaniv Zohar, Estee Kurant, Norman Zilke, Martin Eilers, Amir Orian
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cells
Subjects:
HECT
HUWE1
ubiquitin
salivary gland
endoreplication
JNK
dMyc
dmP53
Online Access:http://www.mdpi.com/2073-4409/7/10/151

Internet

http://www.mdpi.com/2073-4409/7/10/151

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