From bench to bedside: 64Cu/177Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications

From bench to bedside: 64Cu/177Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications

Abstract The development of diagnostic and therapeutic radiopharmaceuticals is an hot topic in nuclear medicine. Several radiolabeled antibodies are under development necessitating both biokinetic and dosimetry extrapolations for effective human translation. The validation of different animal-to-hum...

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Bibliographic Details
Main Authors: Silvano Gnesin, Nicolas Chouin, Michel Cherel, Steven Mark Dunn, Niklaus Schaefer, Alain Faivre-Chauvet, John O. Prior, Judith Anna Delage
Format: Article
Language:English
Published: SpringerOpen 2023-06-01
Series:EJNMMI Research
Subjects:
Theranostic
Fusion protein antibody
Tumor endothelial marker 1
Copper-64
Lutetium-177
PET imaging
Online Access:https://doi.org/10.1186/s13550-023-01010-4

Internet

https://doi.org/10.1186/s13550-023-01010-4

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