Decoding F508del Misfolding in Cystic Fibrosis

Decoding F508del Misfolding in Cystic Fibrosis

The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis. The deletion of a phenylalanine at residue 508 (F508del) is the most common cause of CFTR misfolding leading to the disease. T...

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Bibliographic Details
Main Authors: Xiaodong Robert Wang, Chenglong Li
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Biomolecules
Subjects:
ABC transporter
CFTR
cystic fibrosis
drug discovery
F508del
molecular dynamics simulation
nucleotide-binding domain
protein conformation
protein folding
protein stability
Online Access:http://www.mdpi.com/2218-273X/4/2/498

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http://www.mdpi.com/2218-273X/4/2/498

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