Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects

Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects

A lack of specificity is restricting the further application of conotoxin from Conus bullatus (BuIA). In this study, an analogue library of BuIA was established and virtual screening was used, which identified high α7 nicotinic acetylcholine receptor (nAChR)-selectivity analogues. The anal...

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Bibliographic Details
Main Authors: Chen Liu, Pengxiang Wu, He Zhu, Paolo Grieco, Ruihe Yu, Xinmei Gao, Guiyue Wu, Dong Wang, Hanmei Xu, Weiyan Qi
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
conotoxin
nAChR
analgesia
side effects
Online Access:http://www.mdpi.com/1420-3049/24/2/337

Internet

http://www.mdpi.com/1420-3049/24/2/337

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