Repurposing of High-Dose Erythropoietin as a Potential Drug Attenuates Sepsis in Preconditioning Renal Injury

Repurposing of High-Dose Erythropoietin as a Potential Drug Attenuates Sepsis in Preconditioning Renal Injury

Due to (i) the uremia-enhanced sepsis severity, (ii) the high prevalence of sepsis with pre-existing renal injury and (iii) the non-erythropoiesis immunomodulation of erythropoietin (EPO), EPO was tested in sepsis with pre-existing renal injury models with the retrospective exploration in patients....

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Bibliographic Details
Main Authors: Wiwat Chancharoenthana, Kanyarat Udompronpitak, Yolradee Manochantr, Piyawat Kantagowit, Ponthakorn Kaewkanha, Jiraporn Issara-Amphorn, Asada Leelahavanichkul
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
cecal ligation and puncture
erythropoietin
LPS
macrophages
mortality rate
sepsis
Online Access:https://www.mdpi.com/2073-4409/10/11/3133

Internet

https://www.mdpi.com/2073-4409/10/11/3133

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