Proteomic Analysis of Zika Virus Infected Primary Human Fetal Neural Progenitors Suggests a Role for Doublecortin in the Pathological Consequences of Infection in the Cortex

Proteomic Analysis of Zika Virus Infected Primary Human Fetal Neural Progenitors Suggests a Role for Doublecortin in the Pathological Consequences of Infection in the Cortex

Zika virus (ZIKV) infection is associated with severe neurological defects in fetuses and newborns, such as microcephaly. However, the underlying mechanisms remain to be elucidated. In this study, proteomic analysis on ZIKV-infected primary human fetal neural progenitor cells (NPCs) revealed that vi...

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Bibliographic Details
Main Authors: Xuan Jiang, Xiao Dong, Shi-Hua Li, Yue-Peng Zhou, Simon Rayner, Hui-Min Xia, George F. Gao, Hui Yuan, Ya-Ping Tang, Min-Hua Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Microbiology
Subjects:
Zika virus
human fetal neural progenitor cells (NPCs)
doublecortin (DCX)
cortex structure
proteomic analysis
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01067/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01067/full

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