Structural Insights into the Ligand–LsrK Kinase Binding Mode: A Step Forward in the Discovery of Novel Antimicrobial Agents

Structural Insights into the Ligand–LsrK Kinase Binding Mode: A Step Forward in the Discovery of Novel Antimicrobial Agents

LsrK is a bacterial kinase that triggers the quorum sensing, and it represents a druggable target for the identification of new agents for fighting antimicrobial resistance. Herein, we exploited tryptophan fluorescence spectroscopy (TFS) as a suitable technique for the identification of potential Ls...

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Bibliographic Details
Main Authors: Roberta Listro, Giorgio Milli, Angelica Pellegrini, Chiara Motta, Valeria Cavalloro, Emanuela Martino, Johannes Kirchmair, Giampiero Pietrocola, Daniela Rossi, Pasquale Linciano, Simona Collina
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
LsrK
antimicrobial resistance
tryptophan fluorescence spectroscopy
circular dichroism
docking
screening
Online Access:https://www.mdpi.com/1420-3049/28/6/2542

Internet

https://www.mdpi.com/1420-3049/28/6/2542

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