Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase in vitro and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats

Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase in vitro and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats

Conventional tobacco cigarettes appear to have greater abuse liability than non-combusted products such as electronic cigarettes (ECs) and nicotine replacement therapy (NRT). This may be due to the higher levels of behaviorally active non-nicotine constituents [e.g., monoamine oxidase (MAO) inhibito...

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Bibliographic Details
Main Authors: Andrew C. Harris, Peter Muelken, Aleksandra Alcheva, Irina Stepanov, Mark G. LeSage
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Neuroscience
Subjects:
nicotine
monoamine oxidase (MAO) inhibition
cigarette smoke
e-cigarette
extract
intracranial self-stimulation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.868088/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.868088/full

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