Regulation of Survival Motor Neuron Gene Expression by Calcium Signaling

Regulation of Survival Motor Neuron Gene Expression by Calcium Signaling

Spinal muscular atrophy (SMA) is caused by homozygous <i>survival of motor neurons 1</i> (<i>SMN1</i>) gene deletion, leaving a duplicate gene, <i>SMN2</i>, as the sole source of SMN protein. However, a defect in SMN2 splicing, involving exon 7 skipping, results i...

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Bibliographic Details
Main Authors: Kwangman Choi, Ansook Yang, Jiyeon Baek, Hyejeong Jeong, Yura Kang, Woosun Baek, Joon-Chul Kim, Mingu Kang, Miri Choi, Youngwook Ham, Min-Jeong Son, Sang-Bae Han, Janghwan Kim, Jae-Hyuk Jang, Jong Seog Ahn, Haihong Shen, Sun-Hee Woo, Jong Heon Kim, Sungchan Cho
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
spinal muscular atrophy (SMA)
neuromuscular disease
SMN
pre-mRNA splicing
splicing modulator
calcium signaling
Online Access:https://www.mdpi.com/1422-0067/22/19/10234

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https://www.mdpi.com/1422-0067/22/19/10234

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