Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways. Structural studies to date have elaborated the mechanism of how mutations located...

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Bibliographic Details
Main Authors: Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit
Format: Article
Language:English
Published: The Royal Society 2022-01-01
Series:Open Biology
Subjects:
PINK1
kinase
mitochondria
translocase
phosphorylation
Parkinson's disease
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210264

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https://royalsocietypublishing.org/doi/10.1098/rsob.210264

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