Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas

Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas

By generating protein diversity, alternative splicing provides an important oncogenic pathway. Isocitrate dehydrogenase (<i>IDH</i>) 1 and 2 mutations and 1p/19q co-deletion have become crucial for the novel molecular classification of diffuse gliomas, which also incorporates DNA methyla...

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Bibliographic Details
Main Authors: Lu Zhang, Sabrina Fritah, Petr V. Nazarov, Tony Kaoma, Eric Van Dyck
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
diffuse gliomas
isocitrate dehydrogenase (IDH)
1p/19q co-deletion
G-CIMP
pre-mRNA splicing
alternative splicing
Online Access:https://www.mdpi.com/1422-0067/24/12/9825

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https://www.mdpi.com/1422-0067/24/12/9825

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