The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation

Feline leukemia virus subgroup C receptor 1 (Flvcr1) encodes two heme exporters: FLVCR1a, which localizes to the plasma membrane, and FLVCR1b, which localizes to mitochondria. Here, we investigated the role of the two Flvcr1 isoforms during erythropoiesis. We showed that, in mice and zebrafish, Flvc...

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Bibliographic Details
Main Authors: Sonia Mercurio, Sara Petrillo, Deborah Chiabrando, Zuni Irma Bassi, Dafne Gays, Annalisa Camporeale, Andrei Vacaru, Barbara Miniscalco, Giulio Valperga, Lorenzo Silengo, Fiorella Altruda, Margaret H. Baron, Massimo Mattia Santoro, Emanuela Tolosano
Format: Article
Language:English
Published: Ferrata Storti Foundation 2015-06-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/7402

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https://haematologica.org/article/view/7402

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