Epigenetically Downregulated Breast Cancer Gene 2 through Acetyltransferase Lysine Acetyltransferase 2B Increases the Sensitivity of Colorectal Cancer to Olaparib

Olaparib suppresses DNA damage repair by inhibiting the poly ADP ribose polymerase (PARP), especially in cancers with <i>BRCA1/2</i> mutations or the BRCA-ness phenotype. However, the first trials showed that some patients with defective DNA damage repair are still resistant to olaparib....

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Bibliographic Details
Main Authors: Siche Chen, Heike Allgayer
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/15/23/5580