Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis

Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis

Abstract Background We recently reported that enhanced [18F]-fluorodeoxyglucose (FDG) uptake in skeletal muscles predicts disease aggressiveness in patients with amyotrophic lateral sclerosis (ALS). The present experimental study aimed to assess whether this predictive potential reflects the link be...

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Main Authors: Cecilia Marini, Vanessa Cossu, Tiziana Bonifacino, Matteo Bauckneht, Carola Torazza, Silvia Bruno, Patrizia Castellani, Silvia Ravera, Marco Milanese, Consuelo Venturi, Sebastiano Carlone, Patrizia Piccioli, Laura Emionite, Silvia Morbelli, Anna Maria Orengo, Maria Isabella Donegani, Alberto Miceli, Stefano Raffa, Stefano Marra, Alessio Signori, Katia Cortese, Federica Grillo, Roberto Fiocca, Giambattista Bonanno, Gianmario Sambuceti
Format: Article
Language:English
Published: SpringerOpen 2020-07-01
Series:EJNMMI Research
Subjects:
Amyotrophic lateral sclerosis
SOD1G93A mouse model
[18F]-Fluorodeoxyglucose
Skeletal muscle
Oxidative stress
Endoplasmic reticulum
Online Access:http://link.springer.com/article/10.1186/s13550-020-00666-6

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http://link.springer.com/article/10.1186/s13550-020-00666-6

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