Desmoplastic small round cell tumor: from genomics to targets, potential paths to future therapeutics

Desmoplastic small round cell tumor: from genomics to targets, potential paths to future therapeutics

Desmoplastic Small Round Cell Tumor (DSRCT) is a highly aggressive pediatric cancer caused by a reciprocal translocation between chromosomes 11 and 22, leading to the formation of the EWSR1::WT1 oncoprotein. DSRCT presents most commonly in the abdominal and pelvic peritoneum and remains refractory t...

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Bibliographic Details
Main Authors: Justin W. Magrath, Madelyn Espinosa-Cotton, Dane A. Flinchum, Shruthi Sanjitha Sampath, Nai Kong Cheung, Sean B. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DSRCT
pediatric cancer
sarcoma
fusion oncogene
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1442488/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2024.1442488/full

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