An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death signaling during pyroptosis is fragmented. Her...

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Bibliographic Details
Main Authors: Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
pyroptosis
apoptosis
caspase-1
GSDMD
inflammasome
caspase-8
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309402

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http://www.sciencedirect.com/science/article/pii/S2211124720309402

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