Mitochondrial division inhibitor 1 protects cortical neurons from excitotoxicity: a mechanistic pathway

Mitochondrial division inhibitor 1 protects cortical neurons from excitotoxicity: a mechanistic pathway

Mitochondrial division inhibitor 1 (Mdivi-1) is a selective cell-permeable inhibitor of dynamin-related protein-1 (Drp1) and mitochondrial division. To investigate the effect of Mdivi-1 on cells treated with glutamate, cerebral cortex neurons isolated from neonatal rats were treated with 10 mM gluta...

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Bibliographic Details
Main Authors: Kuai Zhou, Hai-Yuan Yang, Peng-Yu Tang, Wei Liu, Yong-Jun Luo, Bin Lv, Jian Yin, Tao Jiang, Jian Chen, Wei-Hua Cai, Jin Fan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; mitochondrial division inhibitor 1; neurons; apoptosis; mitochondria; division; dynamin-related protein-1; phospho-dynamin-related protein-1; Bax; glutamate; colocalization; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=9;spage=1552;epage=1560;aulast=Zhou

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=9;spage=1552;epage=1560;aulast=Zhou

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