mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

Myelin formation during peripheral nervous system (PNS) development, and reformation after injury and in disease, requires multiple intrinsic and extrinsic signals. Akt/mTOR signaling has emerged as a major player involved, but the molecular mechanisms and downstream effectors are virtually unknown....

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Bibliographic Details
Main Authors: Camilla Norrmén, Gianluca Figlia, Frédéric Lebrun-Julien, Jorge A. Pereira, Martin Trötzmüller, Harald C. Köfeler, Ville Rantanen, Carsten Wessig, Anne-Lieke F. van Deijk, August B. Smit, Mark H.G. Verheijen, Markus A. Rüegg, Michael N. Hall, Ueli Suter
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007694

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http://www.sciencedirect.com/science/article/pii/S2211124714007694

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