Synthesis, Physicochemical and Biological Study of Gallium-68- and Lutetium-177-Labeled VEGF-A<sub>165</sub>/NRP-1 Complex Inhibitors Based on Peptide A7R and Branched Peptidomimetic

Synthesis, Physicochemical and Biological Study of Gallium-68- and Lutetium-177-Labeled VEGF-A<sub>165</sub>/NRP-1 Complex Inhibitors Based on Peptide A7R and Branched Peptidomimetic

Neuropilin-1 (NRP-1) is a surface receptor found on many types of cancer cells. The overexpression of NRP-1 and its interaction with vascular endothelial growth factor-165 (VEGF<sub>165</sub>) are associated with tumor growth and metastasis. Therefore, compounds that block the VEGF<su...

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Bibliographic Details
Main Authors: Katarzyna Masłowska, Ewa Witkowska, Dagmara Tymecka, Paweł Krzysztof Halik, Aleksandra Misicka, Ewa Gniazdowska
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
<sup>68</sup>Ga/<sup>177</sup>Lu-radiopharmaceuticals
cancer therapy
Neuropilin-1
VEGF<sub>165</sub>/NRP-1 complex inhibitor
A7R peptide
peptidomimetics
Online Access:https://www.mdpi.com/1999-4923/14/1/100

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https://www.mdpi.com/1999-4923/14/1/100

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