The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity

The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.

Bibliographic Details
Main Authors: Geng Liu, Wojciech Barczak, Lian Ni Lee, Amit Shrestha, Nicholas M. Provine, Gulsah Albayrak, Hong Zhu, Claire Hutchings, Paul Klenerman, Nicholas B. La Thangue
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04485-y

Internet

https://doi.org/10.1038/s42003-023-04485-y

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