The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04485-y |
| _version_ | 1811175750150127616 |
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| author | Geng Liu Wojciech Barczak Lian Ni Lee Amit Shrestha Nicholas M. Provine Gulsah Albayrak Hong Zhu Claire Hutchings Paul Klenerman Nicholas B. La Thangue |
| author_facet | Geng Liu Wojciech Barczak Lian Ni Lee Amit Shrestha Nicholas M. Provine Gulsah Albayrak Hong Zhu Claire Hutchings Paul Klenerman Nicholas B. La Thangue |
| author_sort | Geng Liu |
| collection | DOAJ |
| description | The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice. |
| first_indexed | 2024-04-10T19:40:57Z |
| format | Article |
| id | doaj.art-677c416326a64b9dac386ff4677a2afa |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-10T19:40:57Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-677c416326a64b9dac386ff4677a2afa2023-01-29T12:19:34ZengNature PortfolioCommunications Biology2399-36422023-01-016111410.1038/s42003-023-04485-yThe HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunityGeng Liu0Wojciech Barczak1Lian Ni Lee2Amit Shrestha3Nicholas M. Provine4Gulsah Albayrak5Hong Zhu6Claire Hutchings7Paul Klenerman8Nicholas B. La Thangue9Laboratory of Cancer Biology, Department of Oncology, University of OxfordLaboratory of Cancer Biology, Department of Oncology, University of OxfordPeter Medawar Building for Pathogen Research, University of OxfordLaboratory of Cancer Biology, Department of Oncology, University of OxfordTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of OxfordLaboratory of Cancer Biology, Department of Oncology, University of OxfordLaboratory of Cancer Biology, Department of Oncology, University of OxfordPeter Medawar Building for Pathogen Research, University of OxfordPeter Medawar Building for Pathogen Research, University of OxfordLaboratory of Cancer Biology, Department of Oncology, University of OxfordThe clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.https://doi.org/10.1038/s42003-023-04485-y |
| spellingShingle | Geng Liu Wojciech Barczak Lian Ni Lee Amit Shrestha Nicholas M. Provine Gulsah Albayrak Hong Zhu Claire Hutchings Paul Klenerman Nicholas B. La Thangue The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity Communications Biology |
| title | The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity |
| title_full | The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity |
| title_fullStr | The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity |
| title_full_unstemmed | The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity |
| title_short | The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity |
| title_sort | hdac inhibitor zabadinostat is a systemic regulator of adaptive immunity |
| url | https://doi.org/10.1038/s42003-023-04485-y |
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