Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.

Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.

There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of t...

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Bibliographic Details
Main Authors: Md Niaz Rahim, Edmund G Wee, Shihua He, Jonathan Audet, Kevin Tierney, Nathifa Moyo, Zara Hannoun, Alison Crook, Andrea Baines, Bette Korber, Xiangguo Qiu, Tomáš Hanke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007564

Internet

https://doi.org/10.1371/journal.ppat.1007564

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