Regular multivitamin supplement use, single nucleotide polymorphisms in ATIC, SHMT2 and SLC46A1 and risk of ovarian carcinoma

Regular multivitamin supplement use, single nucleotide polymorphisms in ATIC, SHMT2 and SLC46A1 and risk of ovarian carcinoma

ATIC, SHMT2 and SLC46A1 have essential roles in one-carbon (1-C) transfer. The authors examined whether associations between ovarian carcinoma and 15 variants in these genes are modified by regular multivitamin use, a source of 1-C donors, among Caucasian participants from two U.S. case control stud...

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Bibliographic Details
Main Authors: Linda E Kelemen, Qinggang eWang, Irina eDinu, Robert A Vierkant, Ya-Yu eTsai, Julie M Cunningham, Cathy M Phelan, Brooke L Fridley, Ernest eAmankwah, Edwin S Iversen, Andrew eBerchuck, Joellen M Schildkraut, Ellen L Goode, Thomas A. Sellers
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-03-01
Series:Frontiers in Genetics
Subjects:
Autophagy
Pyrimidines
Genotype
effect modification
multivitamin
one-carbon transfer
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00033/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00033/full

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