TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation

TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation

Abstract Background Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is required to develop alternative therapeutic strategies. Methods The lung fibroblasts from IPF patients and Reticulocalb...

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Bibliographic Details
Main Authors: Mingting Wu, Zhenyan Wang, Xiaoqian Shi, Danni Zan, Hong Chen, Shuqiao Yang, Fangping Ding, Liu Yang, Pingping Tan, Runlin Z. Ma, Jing Wang, Lishuang Ma, Yingmin Ma, Jiawei Jin
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Respiratory Research
Subjects:
Reticulocalbin 3
Pulmonary fibrosis
Fibroblasts
TGFβ1
TGFβ1 receptor type 1 (TGFBR1)
Enhancer of zeste homolog 2 (EZH2)
Online Access:https://doi.org/10.1186/s12931-023-02533-z

Internet

https://doi.org/10.1186/s12931-023-02533-z

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