The Association of Increase of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Proviral Load (PVL) With Infection in HTLV-1-Positive Patients With Rheumatoid Arthritis: A Longitudinal Analysis of Changes in HTLV-1 PVLs in a Single Center Cohort Study
ObjectiveWe evaluated changes of HTLV-1 proviral loads (PVLs) during treatment for rheumatoid arthritis (RA) and investigated whether these changes affect the clinical course in HTLV-1-positive RA patients.MethodsA total of 41 HTLV-1-positive RA patients were analyzed. Their clinical picture includi...
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Frontiers Media S.A.
2022-05-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.887783/full |
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| author | Naoki Iwamoto Naoki Iwamoto Takeshi Araki Ayaka Umetsu Ayuko Takatani Toshiyuki Aramaki Kunihiro Ichinose Kunihiro Ichinose Kaoru Terada Naoyuki Hirakata Yukitaka Ueki Atsushi Kawakami Katsumi Eguchi |
| author_facet | Naoki Iwamoto Naoki Iwamoto Takeshi Araki Ayaka Umetsu Ayuko Takatani Toshiyuki Aramaki Kunihiro Ichinose Kunihiro Ichinose Kaoru Terada Naoyuki Hirakata Yukitaka Ueki Atsushi Kawakami Katsumi Eguchi |
| author_sort | Naoki Iwamoto |
| collection | DOAJ |
| description | ObjectiveWe evaluated changes of HTLV-1 proviral loads (PVLs) during treatment for rheumatoid arthritis (RA) and investigated whether these changes affect the clinical course in HTLV-1-positive RA patients.MethodsA total of 41 HTLV-1-positive RA patients were analyzed. Their clinical picture including disease activity [Disease Activity Score in 28 joints-erythrocyte sedimentation rate (DAS28-ESR), DAS28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI)] and comorbidity were evaluated over a 2-year period. PVLs from peripheral blood mononuclear cells were investigated by real-time polymerase chain reaction (PCR). We investigated whether HTLV-1 PVLs is altered, or which clinical characteristics affect changes of HTLV1-PVLs during 2-year treatment.ResultsClinical disease activity was not changed during the 2-year observational period. The mean HTLV-1 PVL value change from baseline to 2 years was -1.2 copies/1000 PBMCs, which was not statistically significant. No baseline clinical characteristics influenced changes in HTLV-1 PVL. However, a numerical change of HTLV-1 PVLs was increased in 4 patients initiating the new biological/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) at 2−10 months after starting the new b/ts DMARDs (numerical increase was 24.87 copies/1000 PBMCs). Infection occurred in 4 patients, and 3 of those patients showed an increased HTLV-1 PVL. Univariate analysis revealed an association between increase of HTLV-1 PVL and incidence of infection.ConclusionsOver 2 years, HTLV-1 PVL did not significantly change in our HTLV-1-positive RA patients. Individual changes in HTLV-1 PVL were correlated with incidence of infection but not disease activity which indicate that we may take precaution toward infection at the uptick of HTLV-1 PVL in HTLV-1-positive RA patients. |
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| language | English |
| last_indexed | 2024-04-13T08:23:35Z |
| publishDate | 2022-05-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-6785cf40f29c4bbe9fbef3414b7585752022-12-22T02:54:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.887783887783The Association of Increase of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Proviral Load (PVL) With Infection in HTLV-1-Positive Patients With Rheumatoid Arthritis: A Longitudinal Analysis of Changes in HTLV-1 PVLs in a Single Center Cohort StudyNaoki Iwamoto0Naoki Iwamoto1Takeshi Araki2Ayaka Umetsu3Ayuko Takatani4Toshiyuki Aramaki5Kunihiro Ichinose6Kunihiro Ichinose7Kaoru Terada8Naoyuki Hirakata9Yukitaka Ueki10Atsushi Kawakami11Katsumi Eguchi12Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Rheumatology, Sasebo Chuo Hospital, Sasebo, JapanObjectiveWe evaluated changes of HTLV-1 proviral loads (PVLs) during treatment for rheumatoid arthritis (RA) and investigated whether these changes affect the clinical course in HTLV-1-positive RA patients.MethodsA total of 41 HTLV-1-positive RA patients were analyzed. Their clinical picture including disease activity [Disease Activity Score in 28 joints-erythrocyte sedimentation rate (DAS28-ESR), DAS28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI)] and comorbidity were evaluated over a 2-year period. PVLs from peripheral blood mononuclear cells were investigated by real-time polymerase chain reaction (PCR). We investigated whether HTLV-1 PVLs is altered, or which clinical characteristics affect changes of HTLV1-PVLs during 2-year treatment.ResultsClinical disease activity was not changed during the 2-year observational period. The mean HTLV-1 PVL value change from baseline to 2 years was -1.2 copies/1000 PBMCs, which was not statistically significant. No baseline clinical characteristics influenced changes in HTLV-1 PVL. However, a numerical change of HTLV-1 PVLs was increased in 4 patients initiating the new biological/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) at 2−10 months after starting the new b/ts DMARDs (numerical increase was 24.87 copies/1000 PBMCs). Infection occurred in 4 patients, and 3 of those patients showed an increased HTLV-1 PVL. Univariate analysis revealed an association between increase of HTLV-1 PVL and incidence of infection.ConclusionsOver 2 years, HTLV-1 PVL did not significantly change in our HTLV-1-positive RA patients. Individual changes in HTLV-1 PVL were correlated with incidence of infection but not disease activity which indicate that we may take precaution toward infection at the uptick of HTLV-1 PVL in HTLV-1-positive RA patients.https://www.frontiersin.org/articles/10.3389/fimmu.2022.887783/fullrheumatoid arthritishuman T-cell leukemia virus type 1proviral loadinfectionmolecular-targeted therapy |
| spellingShingle | Naoki Iwamoto Naoki Iwamoto Takeshi Araki Ayaka Umetsu Ayuko Takatani Toshiyuki Aramaki Kunihiro Ichinose Kunihiro Ichinose Kaoru Terada Naoyuki Hirakata Yukitaka Ueki Atsushi Kawakami Katsumi Eguchi The Association of Increase of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Proviral Load (PVL) With Infection in HTLV-1-Positive Patients With Rheumatoid Arthritis: A Longitudinal Analysis of Changes in HTLV-1 PVLs in a Single Center Cohort Study Frontiers in Immunology rheumatoid arthritis human T-cell leukemia virus type 1 proviral load infection molecular-targeted therapy |
| title | The Association of Increase of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Proviral Load (PVL) With Infection in HTLV-1-Positive Patients With Rheumatoid Arthritis: A Longitudinal Analysis of Changes in HTLV-1 PVLs in a Single Center Cohort Study |
| title_full | The Association of Increase of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Proviral Load (PVL) With Infection in HTLV-1-Positive Patients With Rheumatoid Arthritis: A Longitudinal Analysis of Changes in HTLV-1 PVLs in a Single Center Cohort Study |
| title_fullStr | The Association of Increase of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Proviral Load (PVL) With Infection in HTLV-1-Positive Patients With Rheumatoid Arthritis: A Longitudinal Analysis of Changes in HTLV-1 PVLs in a Single Center Cohort Study |
| title_full_unstemmed | The Association of Increase of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Proviral Load (PVL) With Infection in HTLV-1-Positive Patients With Rheumatoid Arthritis: A Longitudinal Analysis of Changes in HTLV-1 PVLs in a Single Center Cohort Study |
| title_short | The Association of Increase of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Proviral Load (PVL) With Infection in HTLV-1-Positive Patients With Rheumatoid Arthritis: A Longitudinal Analysis of Changes in HTLV-1 PVLs in a Single Center Cohort Study |
| title_sort | association of increase of human t cell leukemia virus type 1 htlv 1 proviral load pvl with infection in htlv 1 positive patients with rheumatoid arthritis a longitudinal analysis of changes in htlv 1 pvls in a single center cohort study |
| topic | rheumatoid arthritis human T-cell leukemia virus type 1 proviral load infection molecular-targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.887783/full |
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