Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

The most challenging issue facing peptide drug development is producing a molecule with optimal physical properties while maintaining target binding affinity. Masking peptides with protecting groups that can be removed inside the cell, produces a cell-permeable peptide, which theoretically can maint...

Full description

Bibliographic Details
Main Authors: Yuantao Huo, Laura K. Buckton, Jack L. Bennett, Eloise C. Smith, Frances L. Byrne, Kyle L. Hoehn, Marwa N. Rahimi, Shelli R. McAlpine
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
peptide drug delivery
protein-protein interactions
prodrugs
heat shock protein 90
cell permeability
Online Access:http://dx.doi.org/10.1080/14756366.2019.1580276

Internet

http://dx.doi.org/10.1080/14756366.2019.1580276

Similar Items