Differential regulation of self-reactive CD4 T cells in cervical lymph nodes and central nervous system during viral encephalomyelitis

Differential regulation of self-reactive CD4 T cells in cervical lymph nodes and central nervous system during viral encephalomyelitis

Viral infections have long been implicated as triggers of autoimmune diseases, including Multiple Sclerosis (MS), a central nervous system (CNS) inflammatory demyelinating disorder. Epitope spreading, molecular mimicry, cryptic antigen and bystander activation have been implicated as mechanisms resp...

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Bibliographic Details
Main Authors: Carine Savarin, Cornelia C. Bergmann, David R. Hinton, Stephen A. Stohlman
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
Central Nervous System
CD4+ T cells
viral infection
Tr1 cells
FOXP3+ regulatory T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00370/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00370/full

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