Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

Directly injecting naked or lipid nanoparticle (LNP)-encapsulated modified mRNA (modRNA) allows rapid and efficient protein expression. This non-viral technology has been used successfully in modRNA vaccines against SARS-CoV-2. The main challenges in using modRNA vaccines were the initial requiremen...

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Bibliographic Details
Main Authors: Magdalena M. Żak, Keerat Kaur, Jimeen Yoo, Ann Anu Kurian, Matthew Adjmi, Gayatri Mainkar, Seonghun Yoon, Lior Zangi
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
mRNA stability
mRNA delivery
lipid nanoparticle-encapsulated mRNA
Online Access:https://www.mdpi.com/1999-4923/15/9/2176

Internet

https://www.mdpi.com/1999-4923/15/9/2176

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