Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration1

Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration1

Lecithin:cholesteryl acyltransferase (LCAT) deficiency resulting from targeted disruption of the Lcat gene in the mouse is associated with dramatic decreases in HDL concentration and the accumulation of nascent HDL in the plasma. We examined whether LCAT deficiency in mice is associated with a conco...

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Bibliographic Details
Main Authors: Trudy M. Forte, Michael N. Oda, Laura Knoff, Balz Frei, Jung Suh, Judith A.K. Harmony, William D. Stuart, Edward M. Rubin, Dominic S. Ng
Format: Article
Language:English
Published: Elsevier 1999-07-01
Series:Journal of Lipid Research
Subjects:
LCAT deficiency
nascent HDL
lipid hydroperoxides
apoA-I
antioxidative enzymes
fast protein liquid chromatography
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520334891

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http://www.sciencedirect.com/science/article/pii/S0022227520334891

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