Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation.

Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation.

The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH approximately 6.0 or below when it is bound to ANTXR1, but only at pH approximately 5.0 or below when it is b...

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Bibliographic Details
Main Authors: Heather M Scobie, John M Marlett, G Jonah A Rainey, D Borden Lacy, R John Collier, John A T Young
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1824706?pdf=render

Internet

http://europepmc.org/articles/PMC1824706?pdf=render

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