Chemotherapy-Induced Changes in the Lung Microenvironment: The Role of MMP-2 in Facilitating Intravascular Arrest of Breast Cancer Cells

Chemotherapy-Induced Changes in the Lung Microenvironment: The Role of MMP-2 in Facilitating Intravascular Arrest of Breast Cancer Cells

Previously, we showed that mice treated with cyclophosphamide (CTX) 4 days before intravenous injection of breast cancer cells had more cancer cells in the lung at 3 h after cancer injection than control counterparts without CTX. At 4 days after its injection, CTX is already excreted from the mice,...

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Bibliographic Details
Main Authors: Justin D. Middleton, Subhakeertana Sivakumar, Tsonwin Hai
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
chemotherapy
breast cancer metastasis
vascular microenvironment
cancer cell adhesion
basement membrane
matrix metalloprotease 2 (MMP-2)
Online Access:https://www.mdpi.com/1422-0067/22/19/10280

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https://www.mdpi.com/1422-0067/22/19/10280

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