Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity

Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity

Hematopoietic stem cell (HSC) transplantation is curative for malignant and genetic blood disorders, but is limited by donor availability and immune-mismatch. Deriving HSCs from patient-matched embryonic/induced-pluripotent stem cells (ESCs/iPSCs) could address these limitations. Prior efforts in mu...

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Bibliographic Details
Main Authors: Yi-Fen Lu, Patrick Cahan, Samantha Ross, Julie Sahalie, Patricia M. Sousa, Brandon K. Hadland, Wenqing Cai, Erik Serrao, Alan N. Engelman, Irwin D. Bernstein, George Q. Daley
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Cell Reports
Subjects:
hematopoietic stem cell
HSC engineering
ESC-HSC
HoxB4
Notch
adaptive immunity
adult globin
lineage-priming
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716316515

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http://www.sciencedirect.com/science/article/pii/S2211124716316515

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