Efficient Synthesis of 2-Aminoquinazoline Derivatives via Acid-Mediated [4+2] Annulation of <i>N</i>-Benzyl Cyanamides

Efficient Synthesis of 2-Aminoquinazoline Derivatives via Acid-Mediated [4+2] Annulation of <i>N</i>-Benzyl Cyanamides

The synthesis of 2-aminoquinazoline derivatives is achieved by using hydrochloric acid as a mediator in the [4+2] annulation reaction between <i>N</i>-benzyl cyanamides and 2-amino aryl ketones. In addition, 2-amino-4-iminoquinazolines are synthesized by the reaction of 2-aminobenzonitri...

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Bibliographic Details
Main Authors: Zhao-Yi Qin, Chen-Xi Sun, Wen-Wen Zhang, Jun-Ru Li, Yin-Xiang Gong, Wen-Ming Shu, An-Xin Wu
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Catalysts
Subjects:
acid-mediated
[4+2] annulation
<i>N</i>-benzyl cyanamides
2-aminoquinazolines
2-amino-4-iminoquinazolines
Online Access:https://www.mdpi.com/2073-4344/13/11/1447

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https://www.mdpi.com/2073-4344/13/11/1447

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