Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice

Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice

Inactivity causes insulin resistance in skeletal muscle and exacerbates various lifestyle-related diseases. We previously found that 24-h hindlimb cast immobilization (HCI) of the predominantly slow-twitch soleus muscle increased intramyocellular diacylglycerol (IMDG) and insulin resistance by activ...

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Bibliographic Details
Main Authors: Saori Kakehi, Yoshifumi Tamura, Shin-ichi Ikeda, Naoko Kaga, Hikari Taka, Yuya Nishida, Ryuzo Kawamori, Hirotaka Watada
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Physiology
Subjects:
insulin resistance
physical inactivity
high fat diet
skeletal muscle
PTP1B
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1198390/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1198390/full

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