The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation

The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation

Amoxicillin/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial infections, has been associated with drug-induced liver damage. Quercetin (QR), a naturally occurring flavonoid with pleiotropic biological activities, has poor water solubility and low bioavailability. The...

Full description

Bibliographic Details
Main Authors: Mahran Mohamed Abd El-Emam, Mahmoud Mostafa, Amina A. Farag, Heba S. Youssef, Azza S. El-Demerdash, Heba Bayoumi, Mohammed A. Gebba, Sawsan M. El-Halawani, Abdulrahman M. Saleh, Amira M. Badr, Shorouk El Sayed
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Antioxidants
Subjects:
Co-Amox-induced hepatotoxicity
quercetin liposomes
quercetin antioxidant activity
SIRT1, Nrf2 and NF-κB targeting
gut dysbiosis
Online Access:https://www.mdpi.com/2076-3921/12/8/1487

Internet

https://www.mdpi.com/2076-3921/12/8/1487

Similar Items