Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span

Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span

Lysosomal acid lipase (LAL) is essential for the hydrolysis of triglycerides (TG) and cholesteryl esters (CE) in lysosomes. A mouse model created by gene targeting produces no LAL mRNA, protein, or enzyme activity. The lal−/− mice appear normal at birth, survive into adulthood, and are fertile. Mass...

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Bibliographic Details
Main Authors: Hong Du, Martin Heur, Ming Duanmu, Gregory A. Grabowski, David Y. Hui, David P. Witte, Jaya Mishra
Format: Article
Language:English
Published: Elsevier 2001-04-01
Series:Journal of Lipid Research
Subjects:
Wolman disease
cholesteryl ester storage disease
fatty liver
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520303679

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http://www.sciencedirect.com/science/article/pii/S0022227520303679

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