Design, synthesis and evaluation of antitubercular activity of Triclosan analogues
Novel Triclosan mimic diphenyl ether derivatives 4a–k were designed and synthesized with lipophilicity considerably lesser than that of Triclosan. The binding mode of the compounds at the active site of enoyl-ACP reductase was analysed using docking method. The syntheses were carried out with one-po...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-12-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535215002890 |