New Treatment Strategies for IgA Nephropathy: Targeting Plasma Cells as the Main Source of Pathogenic Antibodies

New Treatment Strategies for IgA Nephropathy: Targeting Plasma Cells as the Main Source of Pathogenic Antibodies

Immunoglobulin A nephropathy (IgAN) is a rare autoimmune disorder and the leading cause of biopsy-reported glomerulonephritis (GN) worldwide. Disease progression is driven by the formation and deposition of immune complexes composed of galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1 autoantibodies (a...

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Bibliographic Details
Main Authors: Dita Maixnerova, Delphine El Mehdi, Dana V. Rizk, Hong Zhang, Vladimir Tesar
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Journal of Clinical Medicine
Subjects:
IgA nephropathy
galactose-deficient IgA1
plasma cells
CD38
renal pathology
Online Access:https://www.mdpi.com/2077-0383/11/10/2810

Internet

https://www.mdpi.com/2077-0383/11/10/2810

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