Desmoplastic small round cell tumor cancer stem cell-like cells resist chemotherapy but remain dependent on the EWSR1-WT1 oncoprotein

Desmoplastic small round cell tumor cancer stem cell-like cells resist chemotherapy but remain dependent on the EWSR1-WT1 oncoprotein

Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive pediatric cancer driven by the EWSR1-WT1 fusion oncogene. Combinations of chemotherapy, radiation and surgery are not curative, and the 5-years survival rate is less than 25%. One potential explanation for refractoriness is the exi...

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Bibliographic Details
Main Authors: Justin W. Magrath, Hong-Jun Kang, Alifiani Hartono, Madelyn Espinosa-Cotton, Romel Somwar, Marc Ladanyi, Nai-Kong V. Cheung, Sean B. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DSRCT
pediatric cancer
cancer stem cells
chemoresistance
sarcoma
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1048709/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.1048709/full

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