An allosteric modulator activates BK channels by perturbing coupling between Ca2+ binding and pore opening

An allosteric modulator activates BK channels by perturbing coupling between Ca2+ binding and pore opening

Ca2+ activated BK channels are important for neural and muscle function. Here authors use a compound, BC5, to show that the interface between the cytosolic and voltage sensing domains is a major allosteric pathway for Ca2+ binding to open the channel.

Bibliographic Details
Main Authors: Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L. Magleby, Jonathan R. Silva, Jianhan Chen, Xiaoqin Zou, Jianmin Cui
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34359-6

Internet

https://doi.org/10.1038/s41467-022-34359-6

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