Mitochondrial complex II and reactive oxygen species in disease and therapy
Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological condit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Redox Report |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/13510002.2020.1752002 |
| _version_ | 1818665487844769792 |
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| author | Katerina Hadrava Vanova Michal Kraus Jiri Neuzil Jakub Rohlena |
| author_facet | Katerina Hadrava Vanova Michal Kraus Jiri Neuzil Jakub Rohlena |
| author_sort | Katerina Hadrava Vanova |
| collection | DOAJ |
| description | Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in cancer and other diseases. |
| first_indexed | 2024-12-17T05:49:25Z |
| format | Article |
| id | doaj.art-67b2efa0763044b29ab37ab24fcd3cd6 |
| institution | Directory Open Access Journal |
| issn | 1351-0002 1743-2928 |
| language | English |
| last_indexed | 2024-12-17T05:49:25Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj.art-67b2efa0763044b29ab37ab24fcd3cd62022-12-21T22:01:12ZengTaylor & Francis GroupRedox Report1351-00021743-29282020-01-01251263210.1080/13510002.2020.17520021752002Mitochondrial complex II and reactive oxygen species in disease and therapyKaterina Hadrava Vanova0Michal Kraus1Jiri Neuzil2Jakub Rohlena3Institute of Biotechnology of the Czech Academy of SciencesInstitute of Biotechnology of the Czech Academy of SciencesInstitute of Biotechnology of the Czech Academy of SciencesInstitute of Biotechnology of the Czech Academy of SciencesIncreasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in cancer and other diseases.http://dx.doi.org/10.1080/13510002.2020.1752002respiratory complex iisuccinate dehydrogenasereactive oxygen speciesoxphosmitochondriacancersuccinatetricarboxylic acid cycle |
| spellingShingle | Katerina Hadrava Vanova Michal Kraus Jiri Neuzil Jakub Rohlena Mitochondrial complex II and reactive oxygen species in disease and therapy Redox Report respiratory complex ii succinate dehydrogenase reactive oxygen species oxphos mitochondria cancer succinate tricarboxylic acid cycle |
| title | Mitochondrial complex II and reactive oxygen species in disease and therapy |
| title_full | Mitochondrial complex II and reactive oxygen species in disease and therapy |
| title_fullStr | Mitochondrial complex II and reactive oxygen species in disease and therapy |
| title_full_unstemmed | Mitochondrial complex II and reactive oxygen species in disease and therapy |
| title_short | Mitochondrial complex II and reactive oxygen species in disease and therapy |
| title_sort | mitochondrial complex ii and reactive oxygen species in disease and therapy |
| topic | respiratory complex ii succinate dehydrogenase reactive oxygen species oxphos mitochondria cancer succinate tricarboxylic acid cycle |
| url | http://dx.doi.org/10.1080/13510002.2020.1752002 |
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