Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor

Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor

Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in the human (h) α3β4 nicotinic acetylcholine re...

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Bibliographic Details
Main Authors: Yuan Ma, Qiushi Cao, Mengke Yang, Yue Gao, Shuiping Fu, Wenhao Du, David J. Adams, Tao Jiang, Han-Shen Tae, Rilei Yu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Marine Drugs
Subjects:
conopeptide
nAChR
ACh-evoked currents
allosteric inhibitor
structure–activity relationship
molecular dynamics simulations
Online Access:https://www.mdpi.com/1660-3397/20/8/497

Internet

https://www.mdpi.com/1660-3397/20/8/497

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