Parameters for Irreversible Inactivation of Monoamine Oxidase

Parameters for Irreversible Inactivation of Monoamine Oxidase

The irreversible inhibitors of monoamine oxidases (MAO) slow neurotransmitter metabolism in depression and neurodegenerative diseases. After oxidation by MAO, hydrazines, cyclopropylamines and propargylamines form a covalent adduct with the flavin cofactor. To assist the design of new compounds to c...

Full description

Bibliographic Details
Main Authors: Rona R. Ramsay, Livia Basile, Antonin Maniquet, Stefanie Hagenow, Matteo Pappalardo, Maria Chiara Saija, Sharon D. Bryant, Alen Albreht, Salvatore Guccione
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
FAD
irreversible inhibition
enzyme kinetics
computational modeling
pharmacophore
spectrum
Online Access:https://www.mdpi.com/1420-3049/25/24/5908

Internet

https://www.mdpi.com/1420-3049/25/24/5908

Similar Items