Glial Glutamate Transporter Modulation Prevents Development of Complete Freund’s Adjuvant-Induced Hyperalgesia and Allodynia in Mice

Glial Glutamate Transporter Modulation Prevents Development of Complete Freund’s Adjuvant-Induced Hyperalgesia and Allodynia in Mice

Glial glutamate transporter (GLT-1) modulation in the hippocampus and anterior cingulate cortex (ACC) is critically involved in nociceptive pain. The objective of the study was to investigate the effects of 3-[[(2-methylphenyl) methyl] thio]-6-(2-pyridinyl)-pyridazine (LDN-212320), a GLT-1 activator...

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Bibliographic Details
Main Authors: Ghallab Alotaibi, Amna Khan, Patrick J. Ronan, Kabirullah Lutfy, Shafiqur Rahman
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Brain Sciences
Subjects:
glutamate transporter
chronic pain
astroglia
microglia
LDN-212320
mice
Online Access:https://www.mdpi.com/2076-3425/13/5/807

Internet

https://www.mdpi.com/2076-3425/13/5/807

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